Characteristics of sodium-proton antiporter of embryo cells and cancer cells

• Main Author: Z. Ya. Fedorovych
• Format: Article
• Language: English
• Published: Львівський національний університет імені Івана Франка 2012-04-01
• Series: Біологічні студії
• Subjects: sodium-proton exchanger; blastomere; intracellular ph
• Online Access: http://publications.lnu.edu.ua/journals/index.php/biology/article/view/303

Review presents the structure, regulation, function and biochemical properties on the Na+/H+ exchanger. We cousider factors that influence activation and inhibition of the Na+/H+ exchanger. Review of literature on involving Na+/H+ exchanger in the process of embryonic and tumor cells activation has been carried. Na+/H+ exchanger plays a major role in the pathophysiological processes as hypertension, cancer, tissue or organ hypertrophy. Exchange maintains рНі that for most cells is approximately 7.2, controls cell growth and proliferation, regulates cell volume. Thus, the study of Na+/H+ exchanger of plasma membrane of embryo cell contributes to the understanding of physiological and pathophysiological processes.