THE EFFECT OF BETA GLUCAN OF SACCHAROMYCES CEREVISAE ON THE DECREASE OF ALPHA SYNUCLEIN EXPRESSION IN THE BRAIN SUBSTANTIA NIGRA OF PARKINSON’S WISTAR STRAIN RATS (Rattus novergicus) MODEL INDUCED WITH ROTENONE

• Main Authors: Masruroh Rahayu, Shahdevi Nandar Kurniawan, Machlusil Husna, Hanestya Oky Hermawan
• Format: Article
• Language: English
• Published: University of Brawijaya 2016-01-01
• Series: Malang Neurology Journal
• Subjects: Alpha synuclein; Beta glucan; Parkinson; Saccharomycescerevisae
• Online Access: http://mnj.ub.ac.id/index.php/mnj/article/view/32
• ISSN: 2407-6724; 2442-5001

Background and aims. One of the regenerative therapy modalities in Parkinson is using the beta glucan effect contained in Saccharomyces cerevisae. The purpose of this research is to identify the effect of reduction in alpha synuclein expression on the brain substantia nigra in Parkinson's rat model after given Saccharomyces cerevisae. Methods. This research applied true experimental design by in vivo with draft randomized post test only controlled group design. The sample was divided into five groups, each of them consisted of 5 rats, namely, negative control group, positive control, treatment 1, 2 and 3 (Rotenone + Saccharomyces cerevisae 18 mg/kgBB), 36 mg/kgBB, 72 mg/kgBB which is given for 30 days). Variables measured were the decreasing level of alpha synuclein. Results. There was a significant difference between positive control and negative control group (p = 0000) and treatment group (p = 0.000; 0.000; 0.000); the addition of Saccharomyces cerevisae in treatment 1, 2 and 3 (18mg/kgBB, 36mg/kg/BB, 72mg/kgBB) caused a significant difference compared with positive control group (p = 0.000; 0.000; 0.000); in treatment 1 (18 mg/kgBB) caused insignificant difference in the amount of alpha synuclein expression compared to the treatment 2 (36mg/kgBB) (p = 0.981), but it showed a significant difference in treatment 3 (72mg/kgBB) (p = 0000). Conclusion. The addition of Saccharomyces cerevisae is able to lower the alpha synuclein expression in Parkinson’s Wistar strain rat models significantly with maximum at the dose of 72 mg/kgBB.