Release of Staphylococcus aureus extracellular vesicles and their application as a vaccine platform

Release of Staphylococcus aureus extracellular vesicles and their application as a vaccine platform

Extracellular vesicles (EVs) influence host-pathogen interactions, but EV biogenesis in gram-positive bacteria remains elusive. Here authors characterize EVs from Staphylococcus aureus and show that phenol-soluble modulins and autolysins promote EV biogenesis by disrupting the membrane and cell wall...

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Bibliographic Details
Main Authors: Xiaogang Wang, Christopher D. Thompson, Christopher Weidenmaier, Jean C. Lee
Format: Article
Language:English
Published: Nature Publishing Group 2018-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03847-z
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spelling doaj-f19b7be7eb15436384641271771b100d2021-05-11T09:43:28ZengNature Publishing GroupNature Communications2041-17232018-04-019111310.1038/s41467-018-03847-zRelease of Staphylococcus aureus extracellular vesicles and their application as a vaccine platformXiaogang Wang0Christopher D. Thompson1Christopher Weidenmaier2Jean C. Lee3Division of Infectious Diseases, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical SchoolDivision of Infectious Diseases, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical SchoolInterfaculty Institute for Microbiology and Infection Medicine, University of TuebingenDivision of Infectious Diseases, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical SchoolExtracellular vesicles (EVs) influence host-pathogen interactions, but EV biogenesis in gram-positive bacteria remains elusive. Here authors characterize EVs from Staphylococcus aureus and show that phenol-soluble modulins and autolysins promote EV biogenesis by disrupting the membrane and cell wall.https://doi.org/10.1038/s41467-018-03847-z
collection DOAJ
language English
format Article
sources DOAJ
author Xiaogang Wang
Christopher D. Thompson
Christopher Weidenmaier
Jean C. Lee
spellingShingle Xiaogang Wang
Christopher D. Thompson
Christopher Weidenmaier
Jean C. Lee
Release of Staphylococcus aureus extracellular vesicles and their application as a vaccine platform
Nature Communications
author_facet Xiaogang Wang
Christopher D. Thompson
Christopher Weidenmaier
Jean C. Lee
author_sort Xiaogang Wang
title Release of Staphylococcus aureus extracellular vesicles and their application as a vaccine platform
title_short Release of Staphylococcus aureus extracellular vesicles and their application as a vaccine platform
title_full Release of Staphylococcus aureus extracellular vesicles and their application as a vaccine platform
title_fullStr Release of Staphylococcus aureus extracellular vesicles and their application as a vaccine platform
title_full_unstemmed Release of Staphylococcus aureus extracellular vesicles and their application as a vaccine platform
title_sort release of staphylococcus aureus extracellular vesicles and their application as a vaccine platform
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-04-01
description Extracellular vesicles (EVs) influence host-pathogen interactions, but EV biogenesis in gram-positive bacteria remains elusive. Here authors characterize EVs from Staphylococcus aureus and show that phenol-soluble modulins and autolysins promote EV biogenesis by disrupting the membrane and cell wall.
url https://doi.org/10.1038/s41467-018-03847-z
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AT christopherweidenmaier releaseofstaphylococcusaureusextracellularvesiclesandtheirapplicationasavaccineplatform
AT jeanclee releaseofstaphylococcusaureusextracellularvesiclesandtheirapplicationasavaccineplatform
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