Release of Staphylococcus aureus extracellular vesicles and their application as a vaccine platform

Release of Staphylococcus aureus extracellular vesicles and their application as a vaccine platform

Extracellular vesicles (EVs) influence host-pathogen interactions, but EV biogenesis in gram-positive bacteria remains elusive. Here authors characterize EVs from Staphylococcus aureus and show that phenol-soluble modulins and autolysins promote EV biogenesis by disrupting the membrane and cell wall...

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Bibliographic Details
Main Authors: Xiaogang Wang, Christopher D. Thompson, Christopher Weidenmaier, Jean C. Lee
Format: Article
Language:English
Published: Nature Publishing Group 2018-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03847-z
Description
Summary:Extracellular vesicles (EVs) influence host-pathogen interactions, but EV biogenesis in gram-positive bacteria remains elusive. Here authors characterize EVs from Staphylococcus aureus and show that phenol-soluble modulins and autolysins promote EV biogenesis by disrupting the membrane and cell wall.
ISSN:2041-1723

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