A Pathophysiological Perspective on the SARS-CoV-2 Coagulopathy

A Pathophysiological Perspective on the SARS-CoV-2 Coagulopathy

Abstract. Recent evidence is focusing on the presence of a hypercoagulable state with development of both venous and arterial thromboembolic complications in patients infected with SARS-CoV-2. The ongoing activation of coagulation related to the severity of the illness is further characterized by th...

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Main Authors: Nuray Kusadasi, Maaike Sikma, Albert Huisman, Jan Westerink, Coen Maas, Roger Schutgens
Format: Article
Language:English
Published: Wolters Kluwer 2020-08-01
Series:HemaSphere
Online Access:http://journals.lww.com/10.1097/HS9.0000000000000457
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spelling doaj-f198338200f5454bb39bbe83fb7110192020-11-25T03:12:43ZengWolters KluwerHemaSphere2572-92412020-08-0144e45710.1097/HS9.0000000000000457202008000-00015A Pathophysiological Perspective on the SARS-CoV-2 CoagulopathyNuray KusadasiMaaike SikmaAlbert HuismanJan WesterinkCoen MaasRoger SchutgensAbstract. Recent evidence is focusing on the presence of a hypercoagulable state with development of both venous and arterial thromboembolic complications in patients infected with SARS-CoV-2. The ongoing activation of coagulation related to the severity of the illness is further characterized by thrombotic microangiopathy and endotheliitis. These microangiopathic changes cannot be classified as classical disseminated intravascular coagulation (DIC). In this short review we describe the interaction between coagulation and inflammation with focus on the possible mechanisms that might be involved in SARS-CoV-2 infection associated coagulopathy in the critically ill.http://journals.lww.com/10.1097/HS9.0000000000000457
collection DOAJ
language English
format Article
sources DOAJ
author Nuray Kusadasi
Maaike Sikma
Albert Huisman
Jan Westerink
Coen Maas
Roger Schutgens
spellingShingle Nuray Kusadasi
Maaike Sikma
Albert Huisman
Jan Westerink
Coen Maas
Roger Schutgens
A Pathophysiological Perspective on the SARS-CoV-2 Coagulopathy
HemaSphere
author_facet Nuray Kusadasi
Maaike Sikma
Albert Huisman
Jan Westerink
Coen Maas
Roger Schutgens
author_sort Nuray Kusadasi
title A Pathophysiological Perspective on the SARS-CoV-2 Coagulopathy
title_short A Pathophysiological Perspective on the SARS-CoV-2 Coagulopathy
title_full A Pathophysiological Perspective on the SARS-CoV-2 Coagulopathy
title_fullStr A Pathophysiological Perspective on the SARS-CoV-2 Coagulopathy
title_full_unstemmed A Pathophysiological Perspective on the SARS-CoV-2 Coagulopathy
title_sort pathophysiological perspective on the sars-cov-2 coagulopathy
publisher Wolters Kluwer
series HemaSphere
issn 2572-9241
publishDate 2020-08-01
description Abstract. Recent evidence is focusing on the presence of a hypercoagulable state with development of both venous and arterial thromboembolic complications in patients infected with SARS-CoV-2. The ongoing activation of coagulation related to the severity of the illness is further characterized by thrombotic microangiopathy and endotheliitis. These microangiopathic changes cannot be classified as classical disseminated intravascular coagulation (DIC). In this short review we describe the interaction between coagulation and inflammation with focus on the possible mechanisms that might be involved in SARS-CoV-2 infection associated coagulopathy in the critically ill.
url http://journals.lww.com/10.1097/HS9.0000000000000457
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