Rapid identification and isolation of neuraminidase inhibitors from mockstrawberry (Duchesnea indica Andr.) based on ligand fishing combined with HR-ESI-Q-TOF-MS

Rapid identification and isolation of neuraminidase inhibitors from mockstrawberry (Duchesnea indica Andr.) based on ligand fishing combined with HR-ESI-Q-TOF-MS

Neuraminidase inhibitors (NAIs) are the mainstay antiviral drugs against influenza infection. In this study, a ligand fishing protocol was developed to screen NAIs using neuraminidase immobilized magnetic beads (NA-MB). After verifying the feasibility of NA-MB with an artificial mixture including NA...

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Bibliographic Details
Main Authors: Sifan Luo, Linbo Guo, Caimin Sheng, Yumei Zhao, Ling Chen, Chufang Li, Zhengjin Jiang, Haiyan Tian
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Neuraminidase inhibitors
Duchesnea indica Andr.
Ligand fishing
Magnetic beads
HPLC–Q-TOF-MS
Influenza A
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383520305438

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http://www.sciencedirect.com/science/article/pii/S2211383520305438

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