Synthesis and Drug Delivery Application of Thermo- and pH-Sensitive Hydrogels: Poly(β-CD-co-N-Isopropylacrylamide-co-IAM)

Synthesis and Drug Delivery Application of Thermo- and pH-Sensitive Hydrogels: Poly(β-CD-co-N-Isopropylacrylamide-co-IAM)

Copolymerization of N-isopropylacrylamide (NIPAM), itaconamic acid (IAM; 4-amino-2-methylene-4-oxobutanoic acid) and β-cyclodextrin was investigated in this study. β-cyclodextrin was at first modified by reacting with allyl glycidyl ether to substitute its OH end groups with moieties containing doub...

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Bibliographic Details
Main Authors: Syang-Peng Rwei, Tuan Huynh Nguyen Anh, Whe-Yi Chiang, Tun-Fun Way, Yung-Jia Hsu
Format: Article
Language:English
Published: MDPI AG 2016-12-01
Series:Materials
Subjects:
Keywords: thermo- and pH-sensitive
β-cyclodextrin
N-isopropylacrylamide
intelligent materials
hydrogel
LCST
drug release
atorvastatin
Online Access:http://www.mdpi.com/1996-1944/9/12/1003

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