In-vivo genetic ablation of metabotropic glutamate receptor type 5 slows down disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis

In-vivo genetic ablation of metabotropic glutamate receptor type 5 slows down disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease due to motor neuron (MN) loss. The mechanisms causing selective MN death are largely unknown, thus prejudicing successful pharmacological treatments. Major causes of MN damage are effects downstream of the abnormal glutamate (G...

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Bibliographic Details
Main Authors: Tiziana Bonifacino, Francesca Provenzano, Elena Gallia, Silvia Ravera, Carola Torazza, Simone Bossi, Sara Ferrando, Aldamaria Puliti, Ludo Van Den Bosch, Giambattista Bonanno, Marco Milanese
Format: Article
Language:English
Published: Elsevier 2019-09-01
Series:Neurobiology of Disease
Subjects:
Amyotrophic lateral sclerosis
SOD1G93A mouse
Metabotropic glutamate type 5 receptor
In-vivo
Genetic ablation
Behaviour
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119301214

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