Optical Biosensors Based on Photonic Crystals Supporting Bound States in the Continuum

A novel optical label-free bio-sensing platform based on a new class of resonances supported in a photonic crystal metasurface is reported herein. Molecular binding is detected as a shift in the resonant wavelength of the bound states in the continuum of radiation modes. The new configuration is app...

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Main Authors:	Silvia Romano, Annalisa Lamberti, Mariorosario Masullo, Erika Penzo, Stefano Cabrini, Ivo Rendina, Vito Mocella
Format:	Article
Language:	English
Published:	MDPI AG 2018-03-01
Series:	Materials
Subjects:	photonic crystal bound states in the continuum biosensors protein interaction
Online Access:	http://www.mdpi.com/1996-1944/11/4/526

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spelling	doaj-f174a53804894b2381e0715857ca8bea2020-11-24T22:42:55ZengMDPI AGMaterials1996-19442018-03-0111452610.3390/ma11040526ma11040526Optical Biosensors Based on Photonic Crystals Supporting Bound States in the ContinuumSilvia Romano0Annalisa Lamberti1Mariorosario Masullo2Erika Penzo3Stefano Cabrini4Ivo Rendina5Vito Mocella6Institute for Microelectronics and Microsystems—Unit of Naples—National Council of Research, Via Pietro Castellino, 80131 Naples, ItalyDepartment of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Via S. Pansini 5, 80131 Napoli, ItalyDepartment of Movement Sciences and Wellbeing, University of Naples “Parthenope”, Via Medina 40, 80133 Napoli, ItalyLawrence Berkeley National Laboratory, Molecular Foundry Division, 67 Cyclotron Road, Berkeley, CA 94720, USALawrence Berkeley National Laboratory, Molecular Foundry Division, 67 Cyclotron Road, Berkeley, CA 94720, USAInstitute for Microelectronics and Microsystems—Unit of Naples—National Council of Research, Via Pietro Castellino, 80131 Naples, ItalyInstitute for Microelectronics and Microsystems—Unit of Naples—National Council of Research, Via Pietro Castellino, 80131 Naples, ItalyA novel optical label-free bio-sensing platform based on a new class of resonances supported in a photonic crystal metasurface is reported herein. Molecular binding is detected as a shift in the resonant wavelength of the bound states in the continuum of radiation modes. The new configuration is applied to the recognition of the interaction between protein p53 and its protein regulatory partner murine double minute 2 (MDM2). A detection limit of 66 nM for the protein p53 is found. The device provides an excellent interrogation stability and loss-free operation, requires minimal optical interrogation equipment and can be easily optimized to work in a wide wavelength range.http://www.mdpi.com/1996-1944/11/4/526photonic crystalbound states in the continuumbiosensorsprotein interaction
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Silvia Romano Annalisa Lamberti Mariorosario Masullo Erika Penzo Stefano Cabrini Ivo Rendina Vito Mocella
spellingShingle	Silvia Romano Annalisa Lamberti Mariorosario Masullo Erika Penzo Stefano Cabrini Ivo Rendina Vito Mocella Optical Biosensors Based on Photonic Crystals Supporting Bound States in the Continuum Materials photonic crystal bound states in the continuum biosensors protein interaction
author_facet	Silvia Romano Annalisa Lamberti Mariorosario Masullo Erika Penzo Stefano Cabrini Ivo Rendina Vito Mocella
author_sort	Silvia Romano
title	Optical Biosensors Based on Photonic Crystals Supporting Bound States in the Continuum
title_short	Optical Biosensors Based on Photonic Crystals Supporting Bound States in the Continuum
title_full	Optical Biosensors Based on Photonic Crystals Supporting Bound States in the Continuum
title_fullStr	Optical Biosensors Based on Photonic Crystals Supporting Bound States in the Continuum
title_full_unstemmed	Optical Biosensors Based on Photonic Crystals Supporting Bound States in the Continuum
title_sort	optical biosensors based on photonic crystals supporting bound states in the continuum
publisher	MDPI AG
series	Materials
issn	1996-1944
publishDate	2018-03-01
description	A novel optical label-free bio-sensing platform based on a new class of resonances supported in a photonic crystal metasurface is reported herein. Molecular binding is detected as a shift in the resonant wavelength of the bound states in the continuum of radiation modes. The new configuration is applied to the recognition of the interaction between protein p53 and its protein regulatory partner murine double minute 2 (MDM2). A detection limit of 66 nM for the protein p53 is found. The device provides an excellent interrogation stability and loss-free operation, requires minimal optical interrogation equipment and can be easily optimized to work in a wide wavelength range.
topic	photonic crystal bound states in the continuum biosensors protein interaction
url	http://www.mdpi.com/1996-1944/11/4/526
work_keys_str_mv	AT silviaromano opticalbiosensorsbasedonphotoniccrystalssupportingboundstatesinthecontinuum AT annalisalamberti opticalbiosensorsbasedonphotoniccrystalssupportingboundstatesinthecontinuum AT mariorosariomasullo opticalbiosensorsbasedonphotoniccrystalssupportingboundstatesinthecontinuum AT erikapenzo opticalbiosensorsbasedonphotoniccrystalssupportingboundstatesinthecontinuum AT stefanocabrini opticalbiosensorsbasedonphotoniccrystalssupportingboundstatesinthecontinuum AT ivorendina opticalbiosensorsbasedonphotoniccrystalssupportingboundstatesinthecontinuum AT vitomocella opticalbiosensorsbasedonphotoniccrystalssupportingboundstatesinthecontinuum
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Optical Biosensors Based on Photonic Crystals Supporting Bound States in the Continuum

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