Role of D-aminoacyl-tRNA deacylase beyond chiral proofreading as a cellular defense against glycine mischarging by AlaRS

Role of D-aminoacyl-tRNA deacylase beyond chiral proofreading as a cellular defense against glycine mischarging by AlaRS

Strict L-chiral rejection through Gly-cisPro motif during chiral proofreading underlies the inability of D-aminoacyl-tRNA deacylase (DTD) to discriminate between D-amino acids and achiral glycine. The consequent Gly-tRNAGly ‘misediting paradox’ is resolved by EF-Tu in the cell. Here, we show that DT...

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Bibliographic Details
Main Authors: Komal Ishwar Pawar, Katta Suma, Ayshwarya Seenivasan, Santosh Kumar Kuncha, Satya Brata Routh, Shobha P Kruparani, Rajan Sankaranarayanan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-03-01
Series:eLife
Subjects:
translation
genetic code
amino acids
chirality
tRNA synthetase
Online Access:https://elifesciences.org/articles/24001

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