Computational Insights into Substrate and Site Specificities, Catalytic Mechanism, and Protonation States of the Catalytic Asp Dyad of β-Secretase

Computational Insights into Substrate and Site Specificities, Catalytic Mechanism, and Protonation States of the Catalytic Asp Dyad of β-Secretase

In this review, information regarding substrate and site specificities, catalytic mechanism, and protonation states of the catalytic Asp dyad of β-secretase (BACE1) derived from computational studies has been discussed. BACE1 catalyzes the rate-limiting step in the generation of Alzheimer amyloid be...

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Bibliographic Details
Main Authors:	Arghya Barman, Rajeev Prabhakar
Format:	Article
Language:	English
Published:	Hindawi Limited 2014-01-01
Series:	Scientifica
Online Access:	http://dx.doi.org/10.1155/2014/598728

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