Targeting the Kaposi’s sarcoma-associated herpesvirus genome with the CRISPR-Cas9 platform in latently infected cells

Targeting the Kaposi’s sarcoma-associated herpesvirus genome with the CRISPR-Cas9 platform in latently infected cells

Abstract Background Kaposi’s sarcoma-associated herpesvirus (KSHV) is a transforming gammaherpesvirus. Like other herpesviruses, KSHV infection is for life long and there is no treatment that can cure patients from the virus. In addition, there is an urgent need to target viral genes to study their...

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Bibliographic Details
Main Authors: Coral Orel Haddad, Inna Kalt, Yehuda Shovman, Lei Xia, Yehuda Schlesinger, Ronit Sarid, Oren Parnas
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Virology Journal
Subjects:
CRISPR-Cas9
Kaposi’s sarcoma-associated herpesvirus, KSHV
Latency associated nuclear antigen, LANA
open reading frame 73, orf73
open reading frame 45, orf45
Online Access:https://doi.org/10.1186/s12985-021-01527-x

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