A One-Step Microwave-Assisted Synthetic Method for an O/S-Chemoselective Route to Derivatives of the First Adenosine A3 PET Radiotracer

A One-Step Microwave-Assisted Synthetic Method for an O/S-Chemoselective Route to Derivatives of the First Adenosine A3 PET Radiotracer

The synthesis of reference standards and expected in vivo metabolites of the first adenosine A3 PET radiotracer [18F]FE@SUPPY ([18F]fluoroethyl 4,6-diethyl-5-[(ethyl-sulfanyl)carbonyl]-2-phenylpyridine-3-carboxylate) was achieved by using a straightforward microwave assisted alkylation method, which...

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Bibliographic Details
Main Authors: Karem Shanab, Catharina Neudorfer, Wolfgang Holzer, Markus Mitterhauser, Wolfgang Wadsak, Helmut Spreitzer
Format: Article
Language:English
Published: MDPI AG 2014-04-01
Series:Molecules
Subjects:
chemoselective
alkylation
microwave
adenosine A3
PET
radiotracer
Online Access:http://www.mdpi.com/1420-3049/19/4/4076

Internet

http://www.mdpi.com/1420-3049/19/4/4076

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