valuation of Subclinical Multiple Sclerosis Patients Using Pattern Visual Evoked Potentials and Visual Field Test

• Main Authors: Sinan Bilgin, Süleyman Sami İlker, Ercüment Çavdar
• Format: Article
• Language: English
• Published: Galenos Yayinevi 2014-05-01
• Series: Türk Oftalmoloji Dergisi
• Subjects: Pattern visual evoked potentials; visual field; multiple sclerosis
• Online Access: http://www.oftalmoloji.org/article_6093/Evaluation-Of-Subclinical-Multiple-Sclerosis-Patients-Using-Pattern-Visual-Evoked-Potentials-And-Visual-Field-Test

Objectives: The aim of this study was to evaluate subclinical multiple sclerosis (MS) patients with normal visual acuity using pattern visual evoked potentials (PVEP) test and central 30-2 threshold visual field (VF) test. Materials and Methods: A total of 60 patients, 30 of which had a definitive MS diagnosis and 30 who were healthy volunteers, were included in the study. The participants were divided into the following three groups: Group 1 - optic neuritis (+) MS patients, Group 2 - optic neuritis (-) MS patients, and Group 3 - control group. Using white on white perimetry, SITA FAST central 30-2 threshold VF tests and 1˚-0.3˚ PVEP measurements were performed. MD, PSD, p100 latency (ms), p100 amplitude (µV), and central 0-10˚, 0-20˚, 0-30˚, 10-20˚, 10-30˚, 20-30˚ retina sensitivities (db) were evaluated in all groups. Results: There was a significant difference in all parameters between Group 1 and Group 3 (p<0.05). There was a significant difference in p100 latency 1˚- 0.3˚, p100 amplitude 0.3˚, central 0-30˚, 10-30˚, 20-30˚ between Group 2 and Group 3 (p<0.05). There was no significant difference in the parameters except for p100 amplitude 1˚ between Group 1 and Group 2 (p>0.05). Conclusion: The evaluation of PVEP and central 30˚ VF can be used to monitor disease prognosis in subclinical MS patients. (Turk J Ophthalmol 2014; 44: 207-11)