THE STUDY OF RHEOLOGICAL PROPERTIES OF TREATMENT GEL ON HYDROPHILIC BASIS

• Main Authors: T. A. Shostak, Yu. Ya. Melnyk, V. Y. Skorokhoda
• Format: Article
• Language: English
• Published: Ukrmedknyha Publishing House 2018-03-01
• Series: Фармацевтичний часопис
• Subjects: гель; камедь гуарова; реологічні дослідження; в’язкість.
• Online Access: https://ojs.tdmu.edu.ua/index.php/pharm-chas/article/view/8597

The aim of the work. Determining the rheological properties of gel on the basis of guar gum with a complex dense extract (CDE) of hypericum herbs and calendula flowers and on this basis to make reasonable adjustments to the optimal composition of the gel. Materials and Methods. The subject of the study is a gel based on guar gum from CDE of hypericum herbs and calendula flowers. The determination of rheological properties was carried out at a temperature of 18, 35 and 50 °C applying viscometer Rheomat-30. The studies were carried out in shear field from 1 s-1 to 200 s-1 using coaxial cylinders. Results and Discussion. It has been defined that the developed gel is a non-Newtonian liquid; it has a plastic type of fluidity and slight thixotropic properties. The change of temperature in the range of 18, 35 and 50°C has almost no effect on the type of flow. With an increase in temperature, a slight decrease in viscosity is observed, which will provide the necessary parameters of the technological process and satisfactory consumer characteristics, in particular, good daubing properties and the ability to extrude from tubes. The formation of a stable gel structure indicates the prospect of using guar gum during processing of drugs that can be stored at different temperature conditions. Conclusion. There have been studied rheological properties of a gel with a guar gum on a hydrophilic basis with a complex dense extract of hypericum herbs and calendula flowers that is intended to treat wound processes in the second and third phases as well as oral mucosa diseases. According to the results of the studies there has been defined the dependence of the structural and mechanical properties of the gel on temperature and respective rheograms have been constructed.