An UPLC-MS/MS method to monitor Estriol injection and comparison of pharmacokinetic characteristics after irradiation

An UPLC-MS/MS method to monitor Estriol injection and comparison of pharmacokinetic characteristics after irradiation

Objective: To develop an UPLC-MS/MS method for the accurate quantification of Estriol (E3), a new radioprotective agent, and observe the variation in pharmacokinetic characteristics of E3 after irradiation. As a hormone drug, the gender differences of E3 metabolism were also concerned here. Methods:...

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Bibliographic Details
Main Authors: Hanming Zhang, Zhiyun Meng, Tong Ye, Taoyun Liu, Jian Li, Fei Ma, Ruolan Gu, Xiaoxia Zhu, Zhuona Wu, Guifang Dou, Hui Gan
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2021-06-01
Series:Radiation Medicine and Protection
Subjects:
Estriol (E3)
Radioprotective agent
Pharmacokinetics
UPLC–MS/MS
Irradiation
Online Access:http://www.sciencedirect.com/science/article/pii/S2666555721000277

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