Metabolic Activation and Carcinogenesis of Tobacco-Specific Nitrosamine N’-Nitrosonornicotine (NNN): A Density Function Theory and Molecular Docking Study

Metabolic Activation and Carcinogenesis of Tobacco-Specific Nitrosamine N’-Nitrosonornicotine (NNN): A Density Function Theory and Molecular Docking Study

N’-nitrosonornicotine (NNN) is one of the tobacco-specific nitrosamines (TSNAs) that exists widely in smoke and smokeless tobacco products. NNN can induce tumors in various laboratory animal models and has been identified by International Agency for Research on Cancer (IARC) as a human car...

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Bibliographic Details
Main Authors: Tengjiao Fan, Guohui Sun, Lijiao Zhao, Xin Cui, Rugang Zhong
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:International Journal of Environmental Research and Public Health
Subjects:
N’-nitrosonornicotine
metabolic activation
carcinogenesis
density functional theory
molecular docking
Online Access:http://www.mdpi.com/1660-4601/16/2/178

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