Actin-Binding Proteins in Nerve Cell Growth Cones

Actin-Binding Proteins in Nerve Cell Growth Cones

The motility of the growth cone, an intracellular apparatus located at the tip of the axon in developing neurons, is thought to govern axonal path-finding and the construction of neuronal networks. Growth cones contain an actin-rich cytoskeleton, and their dynamics are regulated by a wide variety of...

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Main Authors: Ryoki Ishikawa, Kazuhiro Kohama
Format: Article
Language:English
Published: Elsevier 2007-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319342100
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spelling doaj-f12b184bb71e4a34a37ed64eafe9e5542020-11-25T01:48:50ZengElsevierJournal of Pharmacological Sciences1347-86132007-01-011051611Actin-Binding Proteins in Nerve Cell Growth ConesRyoki Ishikawa0Kazuhiro Kohama1Department of Molecular and Cellular Pharmacology, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8511, Japan; Corresponding author. ryoki1@med.gunma-u.ac.jpDepartment of Molecular and Cellular Pharmacology, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8511, JapanThe motility of the growth cone, an intracellular apparatus located at the tip of the axon in developing neurons, is thought to govern axonal path-finding and the construction of neuronal networks. Growth cones contain an actin-rich cytoskeleton, and their dynamics are regulated by a wide variety of actin-binding proteins and motor proteins. In this review, we will focus on the principal functions of these proteins, their mutual interactions in vitro, and their possible roles in the dynamics of nerve cell growth cones. Keywords:: actin, myosin, actin-binding protein, growth cone dynamics, neurite elongationhttp://www.sciencedirect.com/science/article/pii/S1347861319342100
collection DOAJ
language English
format Article
sources DOAJ
author Ryoki Ishikawa
Kazuhiro Kohama
spellingShingle Ryoki Ishikawa
Kazuhiro Kohama
Actin-Binding Proteins in Nerve Cell Growth Cones
Journal of Pharmacological Sciences
author_facet Ryoki Ishikawa
Kazuhiro Kohama
author_sort Ryoki Ishikawa
title Actin-Binding Proteins in Nerve Cell Growth Cones
title_short Actin-Binding Proteins in Nerve Cell Growth Cones
title_full Actin-Binding Proteins in Nerve Cell Growth Cones
title_fullStr Actin-Binding Proteins in Nerve Cell Growth Cones
title_full_unstemmed Actin-Binding Proteins in Nerve Cell Growth Cones
title_sort actin-binding proteins in nerve cell growth cones
publisher Elsevier
series Journal of Pharmacological Sciences
issn 1347-8613
publishDate 2007-01-01
description The motility of the growth cone, an intracellular apparatus located at the tip of the axon in developing neurons, is thought to govern axonal path-finding and the construction of neuronal networks. Growth cones contain an actin-rich cytoskeleton, and their dynamics are regulated by a wide variety of actin-binding proteins and motor proteins. In this review, we will focus on the principal functions of these proteins, their mutual interactions in vitro, and their possible roles in the dynamics of nerve cell growth cones. Keywords:: actin, myosin, actin-binding protein, growth cone dynamics, neurite elongation
url http://www.sciencedirect.com/science/article/pii/S1347861319342100
work_keys_str_mv AT ryokiishikawa actinbindingproteinsinnervecellgrowthcones
AT kazuhirokohama actinbindingproteinsinnervecellgrowthcones
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