Efficacy, safety, and patient preference of monoamine oxidase B inhibitors in the treatment of Parkinson's disease
Bradley J RobottomDepartment of Neurology, University of Maryland School of Medicine, Baltimore, MD, USAAbstract: Parkinson's disease (PD) is the second most common neurodegenerative disease and the most treatable. Treatment of PD is symptomatic and generally focuses on the replacement o...
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Dove Medical Press
2011-01-01
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| Series: | Patient Preference and Adherence |
| Online Access: | http://www.dovepress.com/efficacy-safety-and-patient-preference-of-monoamine-oxidase-b-inhibito-a6098 |
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doaj-f118d7eed1e04751b3c829975773e4602020-11-24T21:41:32ZengDove Medical PressPatient Preference and Adherence1177-889X2011-01-012011default5764Efficacy, safety, and patient preference of monoamine oxidase B inhibitors in the treatment of Parkinson's diseaseBradley J RobottomBradley J RobottomDepartment of Neurology, University of Maryland School of Medicine, Baltimore, MD, USAAbstract: Parkinson's disease (PD) is the second most common neurodegenerative disease and the most treatable. Treatment of PD is symptomatic and generally focuses on the replacement or augmentation of levodopa. A number of options are available for treatment, both in monotherapy of early PD and to treat complications of advanced PD. This review focuses on rasagiline and selegiline, two medications that belong to a class of antiparkinsonian drugs called monoamine oxidase B (MAO-B) inhibitors. Topics covered in the review include mechanism of action, efficacy in early and advanced PD, effects on disability, the controversy regarding disease modification, safety, and patient preference for MAO-B inhibitors.Keywords: monoamine oxidase inhibitors, rasagiline, selegiline, Parkinson's disease, efficacy, safety http://www.dovepress.com/efficacy-safety-and-patient-preference-of-monoamine-oxidase-b-inhibito-a6098 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Bradley J Robottom |
| spellingShingle |
Bradley J Robottom Efficacy, safety, and patient preference of monoamine oxidase B inhibitors in the treatment of Parkinson's disease Patient Preference and Adherence |
| author_facet |
Bradley J Robottom |
| author_sort |
Bradley J Robottom |
| title |
Efficacy, safety, and patient preference of monoamine oxidase B inhibitors in the treatment of Parkinson's disease |
| title_short |
Efficacy, safety, and patient preference of monoamine oxidase B inhibitors in the treatment of Parkinson's disease |
| title_full |
Efficacy, safety, and patient preference of monoamine oxidase B inhibitors in the treatment of Parkinson's disease |
| title_fullStr |
Efficacy, safety, and patient preference of monoamine oxidase B inhibitors in the treatment of Parkinson's disease |
| title_full_unstemmed |
Efficacy, safety, and patient preference of monoamine oxidase B inhibitors in the treatment of Parkinson's disease |
| title_sort |
efficacy, safety, and patient preference of monoamine oxidase b inhibitors in the treatment of parkinson's disease |
| publisher |
Dove Medical Press |
| series |
Patient Preference and Adherence |
| issn |
1177-889X |
| publishDate |
2011-01-01 |
| description |
Bradley J RobottomDepartment of Neurology, University of Maryland School of Medicine, Baltimore, MD, USAAbstract: Parkinson's disease (PD) is the second most common neurodegenerative disease and the most treatable. Treatment of PD is symptomatic and generally focuses on the replacement or augmentation of levodopa. A number of options are available for treatment, both in monotherapy of early PD and to treat complications of advanced PD. This review focuses on rasagiline and selegiline, two medications that belong to a class of antiparkinsonian drugs called monoamine oxidase B (MAO-B) inhibitors. Topics covered in the review include mechanism of action, efficacy in early and advanced PD, effects on disability, the controversy regarding disease modification, safety, and patient preference for MAO-B inhibitors.Keywords: monoamine oxidase inhibitors, rasagiline, selegiline, Parkinson's disease, efficacy, safety |
| url |
http://www.dovepress.com/efficacy-safety-and-patient-preference-of-monoamine-oxidase-b-inhibito-a6098 |
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