Emergence of a colistin-resistant Escherichia coli clinical isolate harboring mcr-1 in Japan

Emergence of a colistin-resistant Escherichia coli clinical isolate harboring mcr-1 in Japan

The mcr-1 is a gene encoding a phosphoethanolamine transferase, which confers resistance to colistin by transferring phosphoethanolamine to lipid A. We describe here the emergence of a colistin-resistant Escherichia coli clinical isolate harboring plasmid-mediated mcr-1 in Japan. The isolate belonge...

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Main Authors: Tatsuya Tada, Kohei Uechi, Isamu Nakasone, Kayo Shimada, Masashi Nakamatsu, Teruo Kirikae, Jiro Fujita
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:International Journal of Infectious Diseases
Online Access:http://www.sciencedirect.com/science/article/pii/S1201971217302023
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spelling doaj-f114b323d12f4d3780bc140effc188362020-11-25T00:15:23ZengElsevierInternational Journal of Infectious Diseases1201-97121878-35112017-10-0163C212210.1016/j.ijid.2017.07.023Emergence of a colistin-resistant Escherichia coli clinical isolate harboring mcr-1 in JapanTatsuya Tada0Kohei Uechi1Isamu Nakasone2Kayo Shimada3Masashi Nakamatsu4Teruo Kirikae5Jiro Fujita6Department of Microbiology, Juntendo University School of Medicine, Tokyo, JapanDivision of Clinical Laboratory and Blood Transfusion, University Hospital of the Ryukyus, Okinawa, JapanControl and Prevention of Infectious Disease, University Hospital of the Ryukyus, Okinawa, JapanDepartment of Infectious Diseases, Research Institute, National Center for Global Health and Medicine, Tokyo, JapanDepartment of Infectious Diseases, Faculty of the Ryukyus, Okinawa, JapanDepartment of Microbiology, Juntendo University School of Medicine, Tokyo, JapanDepartment of Infectious Diseases, Respiratory, and Digestive Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa, JapanThe mcr-1 is a gene encoding a phosphoethanolamine transferase, which confers resistance to colistin by transferring phosphoethanolamine to lipid A. We describe here the emergence of a colistin-resistant Escherichia coli clinical isolate harboring plasmid-mediated mcr-1 in Japan. The isolate belonged to ST5702 and is suspected to come from livestock and transmitted to human. This is the first report of a clinical isolate harboring mcr-1 in Japan.http://www.sciencedirect.com/science/article/pii/S1201971217302023
collection DOAJ
language English
format Article
sources DOAJ
author Tatsuya Tada
Kohei Uechi
Isamu Nakasone
Kayo Shimada
Masashi Nakamatsu
Teruo Kirikae
Jiro Fujita
spellingShingle Tatsuya Tada
Kohei Uechi
Isamu Nakasone
Kayo Shimada
Masashi Nakamatsu
Teruo Kirikae
Jiro Fujita
Emergence of a colistin-resistant Escherichia coli clinical isolate harboring mcr-1 in Japan
International Journal of Infectious Diseases
author_facet Tatsuya Tada
Kohei Uechi
Isamu Nakasone
Kayo Shimada
Masashi Nakamatsu
Teruo Kirikae
Jiro Fujita
author_sort Tatsuya Tada
title Emergence of a colistin-resistant Escherichia coli clinical isolate harboring mcr-1 in Japan
title_short Emergence of a colistin-resistant Escherichia coli clinical isolate harboring mcr-1 in Japan
title_full Emergence of a colistin-resistant Escherichia coli clinical isolate harboring mcr-1 in Japan
title_fullStr Emergence of a colistin-resistant Escherichia coli clinical isolate harboring mcr-1 in Japan
title_full_unstemmed Emergence of a colistin-resistant Escherichia coli clinical isolate harboring mcr-1 in Japan
title_sort emergence of a colistin-resistant escherichia coli clinical isolate harboring mcr-1 in japan
publisher Elsevier
series International Journal of Infectious Diseases
issn 1201-9712
1878-3511
publishDate 2017-10-01
description The mcr-1 is a gene encoding a phosphoethanolamine transferase, which confers resistance to colistin by transferring phosphoethanolamine to lipid A. We describe here the emergence of a colistin-resistant Escherichia coli clinical isolate harboring plasmid-mediated mcr-1 in Japan. The isolate belonged to ST5702 and is suspected to come from livestock and transmitted to human. This is the first report of a clinical isolate harboring mcr-1 in Japan.
url http://www.sciencedirect.com/science/article/pii/S1201971217302023
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