Comparison between oxidative stress (8-OhdG, MDA) and atherogenic risk (AIP) factors in type 2 diabetics and healthy people: a case-control study

• Main Authors: Masoome Boomi Ghochani Atigh, Arash Ghorbani, Asghar Zarban, Majid Shayesteh, Mohammad Malekaneh, Reyhane Hoshyar
• Format: Article
• Language: fas
• Published: Birjand University of Medical Sciences and Health Services 2017-09-01
• Series: Journal of Birjand University of Medical Sciences
• Subjects: Type 2 Diabetes; MDA; AIP; 8-OHdG.
• Online Access: http://journal.bums.ac.ir/browse.php?a_code=A-10-79-4&slc_lang=en&sid=1
• ISSN: 1607-2197; 2423-6152

Background and Aim: Oxidative stress and atherogenic dyslipidemia are the main complications in type 2 diabetics. The present study aimed at comparing between serum 8-hydroxydeoxyguanosine (8-OHdG) and atherogenic index plasma (ARP) levels in type 2 diabetics and normal people. Materials and Methods: In this study the relevant data of 50 type 2 diabetics ,who had referred to Emam Reza educational hospital and serum samples of random 50 healthy subjects, aged 27-70 yrs, was collected. The levels of 8-OHdG, AIP, and MDA in type II diabetics were measured by means of ELISA and TBARS, respectively. Their lipid profiles and plasma autherogenic indices were assessed through an autoanalyser. Results: The case and control groups were homogenized&nbsp; regarding some demographic components such as age and gender .It was found that serum&nbsp; levels of 8OHdG,MDA, and AIP were significantly higher in the patients compared to the healthy controls ,aged 27-70 yrs (P<0.05, r=0.31). But, no significant relationship was found between 8OHdG and MDA (P=0.91, r=0.02). The high rate of lipid peroxidation and DNA oxidation in type II diabetics can reveal outstanding oxidative stress predisposing them to CVDs complications Conclusion: The lipid peroxidation and DNA oxidation in diabetic patients were indicated high oxidative stress in these patients, which can cause post complications such as cardiovascular disease.