Multicomponent synthesis of 4H-pyran derivatives using KOH loaded calcium oxide as catalyst in solvent free condition

• Main Authors: Archana Dhakar, Rupendra Goyal, Archana Rajput, Manvendra Singh Kaurav, Vinod S. Tomar, Dau D. Agarwal
• Format: Article
• Language: English
• Published: Growing Science 2019-06-01
• Series: Current Chemistry Letters
• Subjects: KOH loaded CaO; Aldehyde; Malononitrile; Ethyl acetoacetate; Knoevenagel condensation reaction
• Online Access: http://www.growingscience.com/ccl/Vol8/ccl_2019_11.pdf
• ISSN: 1927-7296; 1927-730X

A Convenient and green synthesis of 4H-pyran derivatives via one-pot multicomponent reaction of aromatic aldehydes, malononitrile and ethyl acetoacetate using KOH loaded CaO as a catalyst under solvent free condition is reported. The morphology of the catalyst has been characterized by XRD and TEM. This protocol have numerous advantages like lesser reaction time, environment friendly, low cost, easy to separate, and provide higher yield. The synthesized compounds have been characterized and confirmed by different spectroscopic techniques like ¹H NMR, ¹³C NMR, FT- IR, and LC- MS.