甘肃地区人群雌激素受体α-29位基因多态性与HBV感染转归的关系

• Main Author: ZHOU Ning
• Format: Article
• Language: zho
• Published: Editorial Department of Journal of Clinical Hepatology 2014-02-01
• Series: Linchuang Gandanbing Zazhi
• Subjects: hepatitis B virus；receptors; estrogen; polymorphisms; single nucleotide
• Online Access: http://www.lcgdbzz.org/qk_content.asp?id=5694&ClassID=1230125813
• ISSN: 1001-5256; 1001-5256

ObjectiveTo investigate the relationship between estrogen receptor alpha (ERα) gene polymorphisms at position 29 and the outcome of hepatitis B virus (HBV) infection among the population in Gansu, China, and to explore the pathogenesis of chronic hepatitis B (CHB) at the genetic level. MethodsA total of 102 patients with CHB and 106 patients who recovered from HBV infection were included in the study. The ERα gene polymorphisms at position 29 were analyzed by polymerase chain reaction-restriction fragment length polymorphism. The allele frequency was calculated by the gene counting method, and the Hardy-Weinberg equilibrium test was performed. Confounding factors were subjected to unconditional logistic regression analysis. Comparisons of genotype frequency and allele frequency were made by chi-square test (R×C). ResultsThe frequencies of TT genotype and T allele of ERα gene polymorphisms at position 29 were significantly higher in the CHB patients than in the patients in the recovery period of HBV infection (62.7% vs 48.1%, χ2=4.502, P＜0.05; 82.4% vs 69.8%, χ2=4.478, P＜0.05), while the frequencies of CC genotype and C allele were significantly lower in the former than in the latter (12.8% vs 19.8%, χ2=27.219, P＜0.05; 17.6% vs 30.2%, χ2=4.478, P＜0.05). The risk of chronic HBV infection in patients with T allele was 2.018 times that in patients with C allele (OR = 2.018, CI = 1.047-3.891). ConclusionThe ERα gene with TT genotype at position 29 might be the susceptibility gene for chronic HBV infection．