IGF1/IGF1R MITOGENIC PATHWAYS AND IMPLICATIONS IN GB THERAPY

• Main Authors: Oana Alexandru, Cornelia Zaharia, Valerica Tudoric, D.O. Alexandru
• Format: Article
• Language: English
• Published: Amaltea Medical Publishing House 2008-03-01
• Series: Romanian Journal of Neurology
• Subjects: insulin-like growth factor; igf1r; mitogenic pathways; gb; therapy
• Online Access: https://revistemedicale.amaltea.ro/Romanian_Journal_of_NEUROLOGY/Revista_Romana_de_NEUROLOGIE-2008-Nr.1/RJN_2008_1_Art-01.pdf

Glioblastoma (GB), the most frequent human brain cancer commonly exhibit abberant proliferation and diminished apoptosis.The neoplastic transformation of the glial cells is often related to an overexpression of growth factors and upregulation of their signaling pathways. Insulin-like growth factor 1 (IGF1) and insulin-like growth factor receptor 1 (IGF1R) are often abnormally expressed in GB and seem to be interesting therapeutic targets for GB therapy. This mini-review will focus on IGF1/IGF1R mitogenic pathways. It will also present some inhibitors and antisense targeting IGF1, its receptor and their signaling pathways for GB treatment.