Time effect of rutaecarpine on caffeine pharmacokinetics in rats

Time effect of rutaecarpine on caffeine pharmacokinetics in rats

Rutaecarpine is reported as a potent inducer of CYP1A2 enzyme in rats. There are natural herbal supplements containing rutaecarpine that are designed to enhance the CYP1A2-dependent removal of caffeine from blood so that people can have coffee later in the day without causing sleep interference. Thi...

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Bibliographic Details
Main Authors: Rohit Kumar Estari, Jin Dong, William K. Chan, Miki Susanto Park, Zhu Zhou
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Biochemistry and Biophysics Reports
Subjects:
Rutaecarpine
Caffeine
Time-dependent induction
CYP1A2
Rat
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580821002156

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