Neopterin and Tumor Necrosis Factor-α : Two Markers of Monocyte/ Macrophage Activation in a Septic Baboon Model

Neopterin and Tumor Necrosis Factor-α : Two Markers of Monocyte/ Macrophage Activation in a Septic Baboon Model

A hyperdynamic sepsis model in adult baboons was set up to follow the time course of TNF-Cl, endotoxin and neopterin. Continuous intravenous administration of 5.108 CFU/kg live E. coli over 2 hours was followed by a seventy hours observation period. In this experimental set up TNF -Cl shows a pronou...

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Bibliographic Details
Main Authors: Strohmaier W., Bahrami S., Davies J., Redl H., Schlag G.
Format: Article
Language:English
Published: De Gruyter 1991-09-01
Series:Pteridines
Online Access:https://doi.org/10.1515/pteridines.1991.3.3.181
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spelling doaj-f0f8b8400f6c45b89027b6301247a6c42021-09-05T13:59:59ZengDe GruyterPteridines0933-48072195-47201991-09-013318118410.1515/pteridines.1991.3.3.181Neopterin and Tumor Necrosis Factor-α : Two Markers of Monocyte/ Macrophage Activation in a Septic Baboon ModelStrohmaier W.0Bahrami S.1Davies J.2Redl H.3Schlag G.4Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, DonaueschingenstrafJe 13,A-J200 Vienna, AustriaLudwig Boltzmann Institute for Experimental and Clinical Traumatology, DonaueschingenstrafJe 13, A-J200 Vienna, AustriaRoodeplaat Research Laboratories, Pretoria, South AfricaLudwig Boltzmann Institute for Experimental and Clinical Traumatology, DonaueschingenstrafJe 13, A-J200 Vienna, AustriaLudwig Boltzmann Institute for Experimental and Clinical Traumatology, DonaueschingenstrafJe 13, A-J200 Vienna, AustriaA hyperdynamic sepsis model in adult baboons was set up to follow the time course of TNF-Cl, endotoxin and neopterin. Continuous intravenous administration of 5.108 CFU/kg live E. coli over 2 hours was followed by a seventy hours observation period. In this experimental set up TNF -Cl shows a pronounced peak after 2 hours and a return to baseline after 4 hours. By 20 - 24 hours neopterin peaks in this subchronic set up and shows only a reduction to half maximum values during the observation period. Another finding is the fast clearance of bacteria and consecutively LPS from the circulation. We conceive that monocyte/macrophage activation seems to occur on at least two levels. The diagnostic usefulness of neopterin in routine measurement is in part explained by these findings.https://doi.org/10.1515/pteridines.1991.3.3.181
collection DOAJ
language English
format Article
sources DOAJ
author Strohmaier W.
Bahrami S.
Davies J.
Redl H.
Schlag G.
spellingShingle Strohmaier W.
Bahrami S.
Davies J.
Redl H.
Schlag G.
Neopterin and Tumor Necrosis Factor-α : Two Markers of Monocyte/ Macrophage Activation in a Septic Baboon Model
Pteridines
author_facet Strohmaier W.
Bahrami S.
Davies J.
Redl H.
Schlag G.
author_sort Strohmaier W.
title Neopterin and Tumor Necrosis Factor-α : Two Markers of Monocyte/ Macrophage Activation in a Septic Baboon Model
title_short Neopterin and Tumor Necrosis Factor-α : Two Markers of Monocyte/ Macrophage Activation in a Septic Baboon Model
title_full Neopterin and Tumor Necrosis Factor-α : Two Markers of Monocyte/ Macrophage Activation in a Septic Baboon Model
title_fullStr Neopterin and Tumor Necrosis Factor-α : Two Markers of Monocyte/ Macrophage Activation in a Septic Baboon Model
title_full_unstemmed Neopterin and Tumor Necrosis Factor-α : Two Markers of Monocyte/ Macrophage Activation in a Septic Baboon Model
title_sort neopterin and tumor necrosis factor-α : two markers of monocyte/ macrophage activation in a septic baboon model
publisher De Gruyter
series Pteridines
issn 0933-4807
2195-4720
publishDate 1991-09-01
description A hyperdynamic sepsis model in adult baboons was set up to follow the time course of TNF-Cl, endotoxin and neopterin. Continuous intravenous administration of 5.108 CFU/kg live E. coli over 2 hours was followed by a seventy hours observation period. In this experimental set up TNF -Cl shows a pronounced peak after 2 hours and a return to baseline after 4 hours. By 20 - 24 hours neopterin peaks in this subchronic set up and shows only a reduction to half maximum values during the observation period. Another finding is the fast clearance of bacteria and consecutively LPS from the circulation. We conceive that monocyte/macrophage activation seems to occur on at least two levels. The diagnostic usefulness of neopterin in routine measurement is in part explained by these findings.
url https://doi.org/10.1515/pteridines.1991.3.3.181
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AT bahramis neopterinandtumornecrosisfactoratwomarkersofmonocytemacrophageactivationinasepticbaboonmodel
AT daviesj neopterinandtumornecrosisfactoratwomarkersofmonocytemacrophageactivationinasepticbaboonmodel
AT redlh neopterinandtumornecrosisfactoratwomarkersofmonocytemacrophageactivationinasepticbaboonmodel
AT schlagg neopterinandtumornecrosisfactoratwomarkersofmonocytemacrophageactivationinasepticbaboonmodel
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