Regioselective O-Derivatization of Quercetin via Ester Intermediates. An Improved Synthesis of Rhamnetin and Development of a New Mitochondriotropic Derivative

Regioselective O-Derivatization of Quercetin via Ester Intermediates. An Improved Synthesis of Rhamnetin and Development of a New Mitochondriotropic Derivative

The regioselective synthesis of several quercetin (3,3’,4’,5,7-pentahydroxy flavone) tetraesters bearing a single free OH on 5-C was achieved in good yield by proper choice of reaction conditions using common esterification procedures. Tetracetylated quercetin with the free OH on 7-C was selectively...

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Bibliographic Details
Main Authors: Mario Zoratti, Ester Marotta, Spiridione Garbisa, Lucia Biasutto, Federico Rastrelli, Andrea Mattarei, Cristina Paradisi
Format: Article
Language:English
Published: MDPI AG 2010-07-01
Series:Molecules
Subjects:
regioselective alkylation
mitochondrial targeting
quercetin
rhamnetin
polyphenols
Online Access:http://www.mdpi.com/1420-3049/15/7/4722/

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