The Management of Scabies in the 21st Century: Past, Advances and Potentials

• Main Authors: Charlotte Bernigaud, Katja Fischer, Olivier Chosidow
• Format: Article
• Language: English
• Published: Society for Publication of Acta Dermato-Venereologica 2020-04-01
• Series: Acta Dermato-Venereologica
• Subjects: scabies; sarcoptes scabiei; neglected tropical disease; ivermectin; permethrin; moxidectin; acaricide discovery and development; ovicidal
• Online Access: https://www.medicaljournals.se/acta/content/html/10.2340/00015555-3468

Scabies is one of the most common skin diseases worldwide, affecting 150–200 million people yearly. Scabies affects young children in particular, and has the greatest impact in poor overcrowded living conditions. The burden of the disease is now well characterized, including group A Streptococcus and Staphylococcus aureus bacterial superinfections, with reports of nephritis, acute rheumatic fever, or fatal invasive sepsis secondary to scabies. Management of scabies remains largely suboptimal from diagnosis to treatment, and progress in the development of new therapeutic measures leading to cure is urgently needed. This review gives an overview of the current limitations in the management of scabies, an update on recent advances, and outlines prospects for potential improvements.