The Hypothermic Influence on CHOP and Ero1-α in an Endoplasmic Reticulum Stress Model of Cerebral Ischemia

The Hypothermic Influence on CHOP and Ero1-α in an Endoplasmic Reticulum Stress Model of Cerebral Ischemia

Hypoxia induced endoplasmic reticulum stress causes accumulation of unfolded proteins in the endoplasmic reticulum and activates the unfolded protein response, resulting in apoptosis through CCAAT-enhancer-binding protein homologous protein (CHOP) activation. In an in vitro and in vivo model of isch...

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Bibliographic Details
Main Authors: Gagandip K. Poone, Henrik Hasseldam, Nina Munkholm, Rune S. Rasmussen, Nina V. Grønberg, Flemming F. Johansen
Format: Article
Language:English
Published: MDPI AG 2015-05-01
Series:Brain Sciences
Subjects:
brain ischemia
unfolded protein response
transcription factor CHOP
Ero1-α protein
hypoxia-inducible factor-proline dioxygenases
stroke
Online Access:http://www.mdpi.com/2076-3425/5/2/178

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