Neonatal androgenization exacerbates alcohol-induced liver injury in adult rats, an effect abrogated by estrogen.

Alcoholic liver disease (ALD) affects millions of people worldwide and is a major cause of morbidity and mortality. However, fewer than 10% of heavy drinkers progress to later stages of injury, suggesting other factors in ALD development, including environmental exposures and genetics. Females displ...

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Bibliographic Details
Main Authors: Whitney M Ellefson, Ashley M Lakner, Alicia Hamilton, Iain H McKillop, Herbert L Bonkovsky, Nury M Steuerwald, Yvette M Huet, Laura W Schrum
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3243688?pdf=render

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