Potential of the NKG2D/NKG2DL Axis in NK Cell-Mediated Clearance of the HIV-1 Reservoir

Potential of the NKG2D/NKG2DL Axis in NK Cell-Mediated Clearance of the HIV-1 Reservoir

Viral persistency in latently infected CD4<sup>+</sup> T cells despite antiretroviral therapy (ART) represents a major drawback in the fight against HIV-1. Efforts to purge latent HIV-1 have been attempted using latency reversing agents (LRAs) that activate expression of the quiescent vi...

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Bibliographic Details
Main Authors: Maria G. Desimio, Daniela A. Covino, Margherita Doria
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:International Journal of Molecular Sciences
Subjects:
HIV-1 eradication
natural killer (NK) cells
NKG2D
latency reversing agents
immunotherapy
Online Access:https://www.mdpi.com/1422-0067/20/18/4490

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