Exosomal cell-to-cell transmission of alpha synuclein oligomers

Exosomal cell-to-cell transmission of alpha synuclein oligomers

<p>Abstract</p> <p>Background</p> <p>Aggregation of alpha-synuclein (αsyn) and resulting cytotoxicity is a hallmark of sporadic and familial Parkinson’s disease (PD) as well as dementia with Lewy bodies, with recent evidence implicating oligomeric and pre-fibrillar form...

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Bibliographic Details
Main Authors: Danzer Karin M, Kranich Lisa R, Ruf Wolfgang P, Cagsal-Getkin Ozge, Winslow Ashley R, Zhu Liya, Vanderburg Charles R, McLean Pamela J
Format: Article
Language:English
Published: BMC 2012-08-01
Series:Molecular Neurodegeneration
Subjects:
Alpha synuclein
Oligomers
Exosomes
Parkinson’s disease
Aggregation
Secretion
Online Access:http://www.molecularneurodegeneration.com/content/7/1/42

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