Epidemiological behavior of osteosarcoma during the years 2005-2014 in Mexico

• Main Authors: Jose Humberto Rodriguez Franco, Romeo Tecualt Gomez, Ruben Alonso Amaya Zepeda, Adriana Atencio Chan, Alejandra Georgina Cario Mendez, Ruben González Valladares
• Format: Article
• Language: English
• Published: Asociacion Argentina de Ortopedia y Traumatologia 2016-08-01
• Series: Revista de la Asociación Argentina de Ortopedia y Traumatologia
• Subjects: Osteosarcoma; Epidemiología. Osteosarcoma; Epidemiology.
• Online Access: http://ojs.aaot.org.ar/ojsr/index.php/AAOTMAG/article/view/542
• ISSN: 1515-1786; 1852-7434

Introduction: Osteosarcoma represents 15% of bone neoplasms. In Mexico, it accounts for 4.5% of neoplasms and 46.6% to 74% of malignant bone tumors with a slight predominance of teenage males, and between 50% to 80% knee and proximal humerus. Aim: Identify the distribution, relative frequency and tendency of OS and its projection to five years. Material and methods: Epidemiologic study of a patient database with histological diagnosis of OS from 2005 to 2014. Age, gender, diagnosis, location, side and stage with descriptive statistics and dispersion (ds) were analyzed. Results were measured with Pearson’s index and lineal regression analysis by least squares method. Results: 4,744 cases were analyzed. OS had a frequency of 3.29% and it stood for 56.2% of primary malignant bone tumors. Age was 18.6±16.8 years old with more incidence in the second decade of life (54.1%); men to women ratio was 1.64:1. 55.8% occurred in the knee, followed by proximal humerus (7.1%). Predominant histologic subtype was osteoblastic (76.9%). IIB stage was more frequent (77.6%), followed by IIIB (13.8%). To five years, it predicts an increased incidence of OS. Conclusions: This is the largest case series of OS in Latin America. A rising in OS incidence is predicted. It is necessary to identify risk factors to establish this particular behavior.