Long Non-coding RNA in Neuronal Development and Neurological Disorders

Long non-coding RNAs (lncRNAs) are transcripts which are usually more than 200 nt in length, and which do not have the protein-coding capacity. LncRNAs can be categorized based on their generation from distinct DNA elements, or derived from specific RNA processing pathways. During the past several d...

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Main Authors:	Ling Li, Yingliang Zhuang, Xingsen Zhao, Xuekun Li
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2019-01-01
Series:	Frontiers in Genetics
Subjects:	long non-coding RNA gene expression neuronal development neurological disorders mechanism
Online Access:	https://www.frontiersin.org/article/10.3389/fgene.2018.00744/full

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spelling	doaj-f0c0e1e4db4148d48c6cacd8171444322020-11-25T00:10:21ZengFrontiers Media S.A.Frontiers in Genetics1664-80212019-01-01910.3389/fgene.2018.00744436598Long Non-coding RNA in Neuronal Development and Neurological DisordersLing Li0Ling Li1Yingliang Zhuang2Yingliang Zhuang3Xingsen Zhao4Xingsen Zhao5Xuekun Li6Xuekun Li7The Children’s Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaInstitute of Translational Medicine, School of Medicine, Zhejiang University, Hangzhou, ChinaThe Children’s Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaInstitute of Translational Medicine, School of Medicine, Zhejiang University, Hangzhou, ChinaThe Children’s Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaInstitute of Translational Medicine, School of Medicine, Zhejiang University, Hangzhou, ChinaThe Children’s Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaInstitute of Translational Medicine, School of Medicine, Zhejiang University, Hangzhou, ChinaLong non-coding RNAs (lncRNAs) are transcripts which are usually more than 200 nt in length, and which do not have the protein-coding capacity. LncRNAs can be categorized based on their generation from distinct DNA elements, or derived from specific RNA processing pathways. During the past several decades, dramatic progress has been made in understanding the regulatory functions of lncRNAs in diverse biological processes, including RNA processing and editing, cell fate determination, dosage compensation, genomic imprinting and development etc. Dysregulation of lncRNAs is involved in multiple human diseases, especially neurological disorders. In this review, we summarize the recent progress made with regards to the function of lncRNAs and associated molecular mechanisms, focusing on neuronal development and neurological disorders.https://www.frontiersin.org/article/10.3389/fgene.2018.00744/fulllong non-coding RNAgene expressionneuronal developmentneurological disordersmechanism
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Ling Li Ling Li Yingliang Zhuang Yingliang Zhuang Xingsen Zhao Xingsen Zhao Xuekun Li Xuekun Li
spellingShingle	Ling Li Ling Li Yingliang Zhuang Yingliang Zhuang Xingsen Zhao Xingsen Zhao Xuekun Li Xuekun Li Long Non-coding RNA in Neuronal Development and Neurological Disorders Frontiers in Genetics long non-coding RNA gene expression neuronal development neurological disorders mechanism
author_facet	Ling Li Ling Li Yingliang Zhuang Yingliang Zhuang Xingsen Zhao Xingsen Zhao Xuekun Li Xuekun Li
author_sort	Ling Li
title	Long Non-coding RNA in Neuronal Development and Neurological Disorders
title_short	Long Non-coding RNA in Neuronal Development and Neurological Disorders
title_full	Long Non-coding RNA in Neuronal Development and Neurological Disorders
title_fullStr	Long Non-coding RNA in Neuronal Development and Neurological Disorders
title_full_unstemmed	Long Non-coding RNA in Neuronal Development and Neurological Disorders
title_sort	long non-coding rna in neuronal development and neurological disorders
publisher	Frontiers Media S.A.
series	Frontiers in Genetics
issn	1664-8021
publishDate	2019-01-01
description	Long non-coding RNAs (lncRNAs) are transcripts which are usually more than 200 nt in length, and which do not have the protein-coding capacity. LncRNAs can be categorized based on their generation from distinct DNA elements, or derived from specific RNA processing pathways. During the past several decades, dramatic progress has been made in understanding the regulatory functions of lncRNAs in diverse biological processes, including RNA processing and editing, cell fate determination, dosage compensation, genomic imprinting and development etc. Dysregulation of lncRNAs is involved in multiple human diseases, especially neurological disorders. In this review, we summarize the recent progress made with regards to the function of lncRNAs and associated molecular mechanisms, focusing on neuronal development and neurological disorders.
topic	long non-coding RNA gene expression neuronal development neurological disorders mechanism
url	https://www.frontiersin.org/article/10.3389/fgene.2018.00744/full
work_keys_str_mv	AT lingli longnoncodingrnainneuronaldevelopmentandneurologicaldisorders AT lingli longnoncodingrnainneuronaldevelopmentandneurologicaldisorders AT yingliangzhuang longnoncodingrnainneuronaldevelopmentandneurologicaldisorders AT yingliangzhuang longnoncodingrnainneuronaldevelopmentandneurologicaldisorders AT xingsenzhao longnoncodingrnainneuronaldevelopmentandneurologicaldisorders AT xingsenzhao longnoncodingrnainneuronaldevelopmentandneurologicaldisorders AT xuekunli longnoncodingrnainneuronaldevelopmentandneurologicaldisorders AT xuekunli longnoncodingrnainneuronaldevelopmentandneurologicaldisorders
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Long Non-coding RNA in Neuronal Development and Neurological Disorders

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