The effect of silver nanoparticles covered with the Achillea biebersteinii plant extract on angiogenesis of chick chorioallantoic membrane
Background: Angiogenesis is a major event in many diseases such as cancer. Today, using silver nanoparticles in industry and medicine has taken into consideration. The Achillea biebersteinii extract has antibacterial, anti-inflammatory and antioxidant effects. The present study aimed at examining th...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | fas |
| Published: |
Kashan University of Medical Sciences and Health Services
2018-01-01
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| Series: | Fiyz̤ |
| Subjects: | |
| Online Access: | http://feyz.kaums.ac.ir/article-1-3002-en.html |
| Summary: | Background: Angiogenesis is a major event in many diseases such as cancer. Today, using silver nanoparticles in industry and medicine has taken into consideration. The Achillea biebersteinii extract has antibacterial, anti-inflammatory and antioxidant effects. The present study aimed at examining the effects of silver nanoparticles coated with the A. biebersteinii extract on angiogenesis of chick chorioallantoic membrane.
Materials and Methods: In this experimental study, 50 fertilized eggs Ross were randomly divided into 5 groups: the sham and experimental groups 1 to 4. In the second day of incubation, the window was opened on eggs and the eggs were treated with 50, 100, 150 and 200 μg/mL silver nanoparticles. At the twelfth day, the samples were photographed and the number and lengths of vessels around the sponges, the length of crown-rump, fetal weight and blood vessels' hemoglobin levels were recorded and compared with the control group.
Results: The results showed that the 50 μg/mL of silver nanoparticles had no significant effect on the angiogenesis process. However, 100,150 and 200 μg/mL of the nanoparticles doses-dependently decreased the number, length and content of hemoglobin in the blood vessels. Also, fetal weight and crown-rump in concentrations 150 and 200 μg/mL showed a significant decrease compared with the control group (P<0.01).
Conclusion: Silver nanoparticles coated with A. biebersteinii extracts can be considered in the studies of diseases associated with angiogenesis such as cancer. |
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| ISSN: | 1029-7855 2008-9821 |