Transgenic expression of CYP7A1 in LDL receptor-deficient mice blocks diet-induced hypercholesterolemia

Transgenic expression of CYP7A1 in LDL receptor-deficient mice blocks diet-induced hypercholesterolemia

Constitutive expression of a cholesterol-7α-hydroxylase (CYP7A1) transgene in LDL receptor-deficient mice blocked the ability of a cholesterol-enriched diet to increase plasma levels of apolipoprotein B-containing lipoproteins. LDL receptor-deficient mice expressing the CYP7A1 transgene exhibited co...

Full description

Bibliographic Details
Main Authors: Eric P. Ratliff, Alejandra Gutierrez, Roger A. Davis
Format: Article
Language:English
Published: Elsevier 2006-07-01
Series:Journal of Lipid Research
Subjects:
cholesterol-7α-hydroxylase
bile acids
cholesterol
low density lipoprotein receptors
proprotein convertase subtilisin/kexin type 9
Niemann-Pick C1-Like 1 protein
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520331953

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520331953

Similar Items