Liver X receptor agonist ameliorates amyloid β-induced inflammation and apoptosis in retinal pigment epithelial cells by activating SIRT1 signaling cascade

Liver X receptor agonist ameliorates amyloid β-induced inflammation and apoptosis in retinal pigment epithelial cells by activating SIRT1 signaling cascade

Objective To investigate the role of liver X receptor (LXR)-SIRT1 regulatory axis in inflammation and apoptosis of retinal pigment epithelial (RPE) cells induced by β-amyloid (Aβ). Methods Human peripheral blood mononuclear cells (PBMCs) were collected from patients with wet age-related macular dege...

Full description

Bibliographic Details
Main Authors: GAN Min, ZHOU Qiaoya, HONG Meijing, LI Xue, PENG Hui
Format: Article
Language:zho
Published: Editorial Office of Journal of Third Military Medical University 2020-07-01
Series:Di-san junyi daxue xuebao
Subjects:
retinal pigment epithelium
liver x receptor
silencing information regulator 1
β-amyloid
age-related macular degeneration
Online Access:http://aammt.tmmu.edu.cn/Upload/rhtml/202003092.htm

Internet

http://aammt.tmmu.edu.cn/Upload/rhtml/202003092.htm

Similar Items