The chemokine, macrophage inflammatory protein-2γ, reduces the expression of glutamate transporter-1 on astrocytes and increases neuronal sensitivity to glutamate excitotoxicity

The chemokine, macrophage inflammatory protein-2γ, reduces the expression of glutamate transporter-1 on astrocytes and increases neuronal sensitivity to glutamate excitotoxicity

<p>Abstract</p> <p>Background</p> <p>Changes in glutamatergic neurotransmission via decreased glutamate transporter (GLT) activity or expression contributes to multiple neurological disorders. Chemokines and their receptors are involved in neurological diseases but the...

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Bibliographic Details
Main Authors: Fang Jie, Han Deping, Hong Jinsheng, Tan Qi, Tian Yeping
Format: Article
Language:English
Published: BMC 2012-12-01
Series:Journal of Neuroinflammation
Subjects:
Glutamate transporter
Chemokines
MIP-2γ
Astrocyte
Lipid rafts
Online Access:http://www.jneuroinflammation.com/content/9/1/267

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