IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP
The role of IFI16 as a DNA sensor is highly controversial. With support from a Nature Communications back-to-back publication from Almineet al. the authors here provide functional evidence that IFI16 is required for DNA sensing via the cGAS-STING pathway in human macrophages.
Bibliographic Details
| Main Authors: |
K. L. Jønsson,
A. Laustsen,
C. Krapp,
K. A. Skipper,
K. Thavachelvam,
D. Hotter,
J. H. Egedal,
M. Kjolby,
P. Mohammadi,
T. Prabakaran,
L. K. Sørensen,
C. Sun,
S. B. Jensen,
C. K. Holm,
R. J. Lebbink,
M. Johannsen,
M. Nyegaard,
J. G. Mikkelsen,
F. Kirchhoff,
S. R. Paludan,
M. R. Jakobsen |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2017-02-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/ncomms14391
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