Esomeprazole Increases Airway Surface Liquid pH in Primary Cystic Fibrosis Epithelial Cells

Esomeprazole Increases Airway Surface Liquid pH in Primary Cystic Fibrosis Epithelial Cells

Respiratory failure, driven by airways mucus obstruction, chronic inflammation and bacterial infections, is the main cause of mortality and morbidity in people with cystic fibrosis (CF) due to defects in the Cl- and HCO3− transport activity of the CF Transmembrane conductance Regulator (CFTR). Most...

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Bibliographic Details
Main Authors: Livia Delpiano, Joseph J. Thomas, Annabel R. Yates, Sarah J. Rice, Michael A. Gray, Vinciane Saint-Criq
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Pharmacology
Subjects:
airway surface liquid pH
cystic fibrosis
ATP12A
ouabain
proton pump inhibitor
esomeprazole
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01462/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01462/full

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