The abolishment of anesthesia-induced cognitive impairment by timely protection of mitochondria in the developing rat brain: The importance of free oxygen radicals and mitochondrial integrity

The abolishment of anesthesia-induced cognitive impairment by timely protection of mitochondria in the developing rat brain: The importance of free oxygen radicals and mitochondrial integrity

Early exposure to general anesthesia (GA) causes developmental neuroapoptosis in the mammalian brain and long-term cognitive impairment. Recent evidence suggests that GA also causes functional and morphological impairment of the immature neuronal mitochondria. Injured mitochondria could be a signifi...

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Bibliographic Details
Main Authors: A. Boscolo, J.A. Starr, V. Sanchez, N. Lunardi, M.R. DiGruccio, C. Ori, A. Erisir, P. Trimmer, J. Bennett, V. Jevtovic-Todorovic
Format: Article
Language:English
Published: Elsevier 2012-03-01
Series:Neurobiology of Disease
Subjects:
Isoflurane
Lipid peroxidation
Reactive oxygen species
EUK-134
Pramipexole
Learning/memory
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111003974

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