Acute liver failure in Still’s disease relapse during pregnancy: case report and discussion of a possible trigger role of DILI

• Main Authors: Giuseppe Marrone, Francesco Galati, Marco Biolato, Cristopher Oddy, Sara De Carolis, Angelo Zoli, Antonio Grieco
• Format: Article
• Language: English
• Published: BMC 2021-08-01
• Series: BMC Gastroenterology
• Subjects: Acute onset Still’s disease; Acute liver failure; Drug induced liver failure; ALF case report
• Online Access: https://doi.org/10.1186/s12876-021-01878-3

Abstract Background Still's disease is a rare systemic inflammatory disease with frequent but generally mild liver involvement. The most common cause of acute liver failure in western countries is drug-induced liver injury, while it has rarely been reported in subjects suffering from Still’s disease. Case presentation We report a case of a young woman presenting with SD reactivation in pregnancy and acute liver failure after delivery with a possible triggering role of drug induced liver injury. Conclusions The prompt recognition of Still's disease reactivation allowed early introduction of steroid therapy and resolution of the clinical picture. We discuss potential factors precipitating ALF in this case, and implications for the diagnosis and management of such patients.