Diagnosis and management of eosinophilic asthma: a US perspective

Hannah H Walford,1,2 Taylor A Doherty11Department of Medicine, 2Department of Pediatrics, University of California, La Jolla, CA, USAAbstract: Eosinophilic asthma is now recognized as an important subphenotype of asthma based on the pattern of inflammatory cellular infiltrate in the airway. Eosinop...

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Main Authors: Walford HH, Doherty TA
Format: Article
Language:English
Published: Dove Medical Press 2014-04-01
Series:Journal of Asthma and Allergy
Online Access:http://www.dovepress.com/diagnosis-and-management-of-eosinophilic-asthma-a-us-perspective-a16448
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spelling doaj-f06edcef35ac44599708e3c28251ff9d2020-11-24T23:30:07ZengDove Medical PressJournal of Asthma and Allergy1178-69652014-04-012014default536516448Diagnosis and management of eosinophilic asthma: a US perspectiveWalford HHDoherty TA Hannah H Walford,1,2 Taylor A Doherty11Department of Medicine, 2Department of Pediatrics, University of California, La Jolla, CA, USAAbstract: Eosinophilic asthma is now recognized as an important subphenotype of asthma based on the pattern of inflammatory cellular infiltrate in the airway. Eosinophilic asthma can be associated with increased asthma severity, atopy, late-onset disease, and steroid refractoriness. Induced sputum cell count is the gold standard for identifying eosinophilic inflammation in asthma although several noninvasive biomarkers, including fractional exhaled nitric oxide and periostin, are emerging as potential surrogates. As novel therapies and biologic agents become increasingly available, there is an increased need for specific phenotype-directed treatment strategies. Greater recognition and understanding of the unique immunopathology of this asthma phenotype has important implications for management of the disease and the potential to improve patient outcomes. The present review provides a summary of the clinical features, pathogenesis, diagnosis, and management of eosinophilic asthma.Keywords: asthma, eosinophil, allergy, Th2, IL-4, IL-13http://www.dovepress.com/diagnosis-and-management-of-eosinophilic-asthma-a-us-perspective-a16448
collection DOAJ
language English
format Article
sources DOAJ
author Walford HH
Doherty TA
spellingShingle Walford HH
Doherty TA
Diagnosis and management of eosinophilic asthma: a US perspective
Journal of Asthma and Allergy
author_facet Walford HH
Doherty TA
author_sort Walford HH
title Diagnosis and management of eosinophilic asthma: a US perspective
title_short Diagnosis and management of eosinophilic asthma: a US perspective
title_full Diagnosis and management of eosinophilic asthma: a US perspective
title_fullStr Diagnosis and management of eosinophilic asthma: a US perspective
title_full_unstemmed Diagnosis and management of eosinophilic asthma: a US perspective
title_sort diagnosis and management of eosinophilic asthma: a us perspective
publisher Dove Medical Press
series Journal of Asthma and Allergy
issn 1178-6965
publishDate 2014-04-01
description Hannah H Walford,1,2 Taylor A Doherty11Department of Medicine, 2Department of Pediatrics, University of California, La Jolla, CA, USAAbstract: Eosinophilic asthma is now recognized as an important subphenotype of asthma based on the pattern of inflammatory cellular infiltrate in the airway. Eosinophilic asthma can be associated with increased asthma severity, atopy, late-onset disease, and steroid refractoriness. Induced sputum cell count is the gold standard for identifying eosinophilic inflammation in asthma although several noninvasive biomarkers, including fractional exhaled nitric oxide and periostin, are emerging as potential surrogates. As novel therapies and biologic agents become increasingly available, there is an increased need for specific phenotype-directed treatment strategies. Greater recognition and understanding of the unique immunopathology of this asthma phenotype has important implications for management of the disease and the potential to improve patient outcomes. The present review provides a summary of the clinical features, pathogenesis, diagnosis, and management of eosinophilic asthma.Keywords: asthma, eosinophil, allergy, Th2, IL-4, IL-13
url http://www.dovepress.com/diagnosis-and-management-of-eosinophilic-asthma-a-us-perspective-a16448
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