Diagnosis and management of eosinophilic asthma: a US perspective
Hannah H Walford,1,2 Taylor A Doherty11Department of Medicine, 2Department of Pediatrics, University of California, La Jolla, CA, USAAbstract: Eosinophilic asthma is now recognized as an important subphenotype of asthma based on the pattern of inflammatory cellular infiltrate in the airway. Eosinop...
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doaj-f06edcef35ac44599708e3c28251ff9d2020-11-24T23:30:07ZengDove Medical PressJournal of Asthma and Allergy1178-69652014-04-012014default536516448Diagnosis and management of eosinophilic asthma: a US perspectiveWalford HHDoherty TA Hannah H Walford,1,2 Taylor A Doherty11Department of Medicine, 2Department of Pediatrics, University of California, La Jolla, CA, USAAbstract: Eosinophilic asthma is now recognized as an important subphenotype of asthma based on the pattern of inflammatory cellular infiltrate in the airway. Eosinophilic asthma can be associated with increased asthma severity, atopy, late-onset disease, and steroid refractoriness. Induced sputum cell count is the gold standard for identifying eosinophilic inflammation in asthma although several noninvasive biomarkers, including fractional exhaled nitric oxide and periostin, are emerging as potential surrogates. As novel therapies and biologic agents become increasingly available, there is an increased need for specific phenotype-directed treatment strategies. Greater recognition and understanding of the unique immunopathology of this asthma phenotype has important implications for management of the disease and the potential to improve patient outcomes. The present review provides a summary of the clinical features, pathogenesis, diagnosis, and management of eosinophilic asthma.Keywords: asthma, eosinophil, allergy, Th2, IL-4, IL-13http://www.dovepress.com/diagnosis-and-management-of-eosinophilic-asthma-a-us-perspective-a16448 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Walford HH Doherty TA |
spellingShingle |
Walford HH Doherty TA Diagnosis and management of eosinophilic asthma: a US perspective Journal of Asthma and Allergy |
author_facet |
Walford HH Doherty TA |
author_sort |
Walford HH |
title |
Diagnosis and management of eosinophilic asthma: a US perspective |
title_short |
Diagnosis and management of eosinophilic asthma: a US perspective |
title_full |
Diagnosis and management of eosinophilic asthma: a US perspective |
title_fullStr |
Diagnosis and management of eosinophilic asthma: a US perspective |
title_full_unstemmed |
Diagnosis and management of eosinophilic asthma: a US perspective |
title_sort |
diagnosis and management of eosinophilic asthma: a us perspective |
publisher |
Dove Medical Press |
series |
Journal of Asthma and Allergy |
issn |
1178-6965 |
publishDate |
2014-04-01 |
description |
Hannah H Walford,1,2 Taylor A Doherty11Department of Medicine, 2Department of Pediatrics, University of California, La Jolla, CA, USAAbstract: Eosinophilic asthma is now recognized as an important subphenotype of asthma based on the pattern of inflammatory cellular infiltrate in the airway. Eosinophilic asthma can be associated with increased asthma severity, atopy, late-onset disease, and steroid refractoriness. Induced sputum cell count is the gold standard for identifying eosinophilic inflammation in asthma although several noninvasive biomarkers, including fractional exhaled nitric oxide and periostin, are emerging as potential surrogates. As novel therapies and biologic agents become increasingly available, there is an increased need for specific phenotype-directed treatment strategies. Greater recognition and understanding of the unique immunopathology of this asthma phenotype has important implications for management of the disease and the potential to improve patient outcomes. The present review provides a summary of the clinical features, pathogenesis, diagnosis, and management of eosinophilic asthma.Keywords: asthma, eosinophil, allergy, Th2, IL-4, IL-13 |
url |
http://www.dovepress.com/diagnosis-and-management-of-eosinophilic-asthma-a-us-perspective-a16448 |
work_keys_str_mv |
AT walfordhh diagnosisandmanagementofeosinophilicasthmaausperspective AT dohertyta diagnosisandmanagementofeosinophilicasthmaausperspective |
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