Establishing the concept of aza-[3 + 3] annulations using enones as a key expansion of this unified strategy in alkaloid synthesis

Establishing the concept of aza-[3 + 3] annulations using enones as a key expansion of this unified strategy in alkaloid synthesis

A successful enone version of an intramolecular aza-[3 + 3] annulation reaction is described here. Use of piperidinium trifluoroacetate salt as the catalyst and toluene as the solvent appears to be critical for a successful annulation. We also demonstrated for the first time that microwave irradiati...

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Bibliographic Details
Main Authors: Aleksey I. Gerasyuto, Zhi-Xiong Ma, Grant S. Buchanan, Richard P. Hsung
Format: Article
Language:English
Published: Beilstein-Institut 2013-06-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
alkaloids synthesis
catalysis
enones
intramolecular aza-[3 + 3] annulation
N-heterocycles
natural product
vinylogous amides
Online Access:https://doi.org/10.3762/bjoc.9.131

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