Features of Clinical Picture, Course and Treatment of Patients with Gout on the Background of Hypothyroidism

• Main Authors: O.I. Voloshin, O.I. Dogolich, N.V. Pashkovska
• Format: Article
• Language: English
• Published: Publishing House Zaslavsky 2014-04-01
• Series: Mìžnarodnij Endokrinologìčnij Žurnal
• Subjects: gout; hypothyroidism; comorbidity; treatment
• Online Access: http://iej.zaslavsky.com.ua/article/view/76666
• ISSN: 2224-0721; 2307-1427

Aim was to study the prevalence of subclinical and manifest hypothyroidism in patients with gout, its impact on the clinical presentation and course of the disease, correction of treatment by inclusion in a treatment program of and levothyroxine and phytocomplex zobofit. Material and Methods. We examined 127 patients with gout at the age of 37–77 years. The diagnosis of hypothyroidism is established based on defined levels of TSH, free T4, T3, thyroid ultrasound, palpation, assess complaints. Results. The presence of subclinical and manifest hypothyroidism is detected in 19.25 % of the patients, at that the women it was detected 2.3 times more often. Both forms of hypothyroidism worsen gout, contribute to its progression, reducing the effectiveness of treatment and increased polymorbid background. We suggested early screening diagnosis of hypothyroidism in patients with gout over the age of 50–55 years or younger in the case of amplification of clinical manifestations of gout and the deterioration of its course. Applied in antigout treatment with levothyroxine (manifest hypothyroidism) and phytocomplex zobofit (subclinical form) improved clinical dynamics of polymorbid background, indicators of thyroid homeostasis, lipid metabolism and renal glomerular filtration.