Unattached kinetochores drive their own capturing by sequestering a CLASP

Unattached kinetochores drive their own capturing by sequestering a CLASP

Kinetochores (KT) that are not attached to microtubules prevent chromosome missegregation via the spindle assembly checkpoint. Here the authors show that Mps1 localizes Stu1 at unattached KTs together with Slk19, causing a reorganization of the nuclear MT network that favors the capturing of unattac...

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Main Authors: Caroline Kolenda, Jennifer Ortiz, Marina Pelzl, Sarina Norell, Verena Schmeiser, Johannes Lechner
Format: Article
Language:English
Published: Nature Publishing Group 2018-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03108-z
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spelling doaj-f04529f23ed14fd98cef773f570ba4d72021-05-11T10:05:28ZengNature Publishing GroupNature Communications2041-17232018-02-019111510.1038/s41467-018-03108-zUnattached kinetochores drive their own capturing by sequestering a CLASPCaroline Kolenda0Jennifer Ortiz1Marina Pelzl2Sarina Norell3Verena Schmeiser4Johannes Lechner5Biochemie-Zentrum der Universität HeidelbergBiochemie-Zentrum der Universität HeidelbergBiochemie-Zentrum der Universität HeidelbergBiochemie-Zentrum der Universität HeidelbergBiochemie-Zentrum der Universität HeidelbergBiochemie-Zentrum der Universität HeidelbergKinetochores (KT) that are not attached to microtubules prevent chromosome missegregation via the spindle assembly checkpoint. Here the authors show that Mps1 localizes Stu1 at unattached KTs together with Slk19, causing a reorganization of the nuclear MT network that favors the capturing of unattached KT.https://doi.org/10.1038/s41467-018-03108-z
collection DOAJ
language English
format Article
sources DOAJ
author Caroline Kolenda
Jennifer Ortiz
Marina Pelzl
Sarina Norell
Verena Schmeiser
Johannes Lechner
spellingShingle Caroline Kolenda
Jennifer Ortiz
Marina Pelzl
Sarina Norell
Verena Schmeiser
Johannes Lechner
Unattached kinetochores drive their own capturing by sequestering a CLASP
Nature Communications
author_facet Caroline Kolenda
Jennifer Ortiz
Marina Pelzl
Sarina Norell
Verena Schmeiser
Johannes Lechner
author_sort Caroline Kolenda
title Unattached kinetochores drive their own capturing by sequestering a CLASP
title_short Unattached kinetochores drive their own capturing by sequestering a CLASP
title_full Unattached kinetochores drive their own capturing by sequestering a CLASP
title_fullStr Unattached kinetochores drive their own capturing by sequestering a CLASP
title_full_unstemmed Unattached kinetochores drive their own capturing by sequestering a CLASP
title_sort unattached kinetochores drive their own capturing by sequestering a clasp
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-02-01
description Kinetochores (KT) that are not attached to microtubules prevent chromosome missegregation via the spindle assembly checkpoint. Here the authors show that Mps1 localizes Stu1 at unattached KTs together with Slk19, causing a reorganization of the nuclear MT network that favors the capturing of unattached KT.
url https://doi.org/10.1038/s41467-018-03108-z
work_keys_str_mv AT carolinekolenda unattachedkinetochoresdrivetheirowncapturingbysequesteringaclasp
AT jenniferortiz unattachedkinetochoresdrivetheirowncapturingbysequesteringaclasp
AT marinapelzl unattachedkinetochoresdrivetheirowncapturingbysequesteringaclasp
AT sarinanorell unattachedkinetochoresdrivetheirowncapturingbysequesteringaclasp
AT verenaschmeiser unattachedkinetochoresdrivetheirowncapturingbysequesteringaclasp
AT johanneslechner unattachedkinetochoresdrivetheirowncapturingbysequesteringaclasp
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