Leigh Syndrome Mimicking Wernicke’s Encephalopathy: A Case Report
Leigh syndrome or subacute necrotizing encephalomyelopathy is a rare, rapidly progressive neurodegenerative disorder. In general, symptoms such as shortness of breath and decreased cardiac function usually occur within 1 year of life. It is a serious disease with a mortality rate of 75% in 2–3 ye...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
The Korean Society of Radiology
2020-11-01
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| Series: | 대한영상의학회지 |
| Subjects: | |
| Online Access: | https://doi.org/10.3348/jksr.2019.0197 |
| Summary: | Leigh syndrome or subacute necrotizing encephalomyelopathy is a rare, rapidly progressive
neurodegenerative disorder. In general, symptoms such as shortness of breath and decreased
cardiac function usually occur within 1 year of life. It is a serious disease with a mortality rate of
75% in 2–3 years. The cause of Leigh syndrome is DNA mutation. Approximately 75% of patients
have nuclear DNA mutations while 25% have mitochondrial DNA mutations. Clinical
symptoms vary depending on the affected brain area. Neuroimaging plays an important role in
diagnosing patients with Leigh syndrome. Late-onset Leigh syndrome is rarer and progresses
more slowly compared to the classic form. Here, we report a case of late-onset Leigh’s syndrome
mimicking Wernicke’s encephalopathy. |
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| ISSN: | 1738-2637 2288-2928 |