Protein-to-creatinine urinary in the early diagnosis of renal injury in canine pyometra

• Main Authors: Marcos C. Sant’Anna, Guilherme F. Martins, Karina K.M.C. Flaiban, Luiz G.C. Trautwein, Maria I.M. Martins
• Format: Article
• Language: English
• Published: Colégio Brasileiro de Patologia Animal (CBPA)
• Series: Pesquisa Veterinária Brasileira
• Subjects: Proteína; creatinina; sistema urinário; lesão renal; cadelas; piometra; UPC; hiperplasia endometrial cística; proteinúria; caninos; cirurgia
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2019000300186&lng=en&tlng=en

ABSTRACT: Kidney disease that affects bitches with pyometra may lead patients to develop chronic renal failure even after pyometra treatment. Therefore, several studies have sought to clarify the gaps in the understanding of the pathogenesis of renal injury in pyometra. Identification of early detection markers for renal damage, which can predict and identify the prognosis of the disease, is very important. Proteinuria analysis can diagnose kidney damage, since proteins such as albumin are not filtered through the glomerulus and those that undergo glomerular filtration are almost completely reabsorbed by tubular cells. The objective of this study was to evaluate whether the urinary protein-to-creatinine ratio (UPC) can detect renal injury in bitches with pyometra before development of azotemia. For this, 44 bitches with pyometra were divided into two groups: bitches with azotemic piometra (A, n=15, creatinine >1.7) and bitches with non-azotemic pyometra (NA, n=29). The two groups were compared to the control group (CG, n=12), which had no signs of systemic disease. All animals underwent blood and urine tests. Leukocytosis was more evident in bitches in the A group than in the other groups. This shows that the inflammatory response may be associated with the pathogenesis of renal injury. The median UPC in bitches with pyometra was significantly higher than in the CG, with a median above the reference values. In conclusion, the UPC can be used in bitches with pyometra to detect renal damage before the development of azotemia. It has been suggested that the UPC of bitches with pyometra should be followed through during the postoperative period so that permanent renal lesions secondary to pyometra can be diagnosed and treated properly before the development of azotemia.