Combination of multiple computational methods revealing specific sub-sectional recognition and hydrogen-bond dependent transportation of CKII peptide fragment in O-GlcNAc transferase

Combination of multiple computational methods revealing specific sub-sectional recognition and hydrogen-bond dependent transportation of CKII peptide fragment in O-GlcNAc transferase

O-linked β-N-acetyl-D-glucosamine (O-GlcNAc) transferase (OGT) is an essential enzyme in many cellular physiological catalytic reactions that regulates protein O-GlcNAcylation. Aberrant O-GlcNAcylation is related to insulin resistance, diabetic complications, cancer and neurodegenerative diseases. U...

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Bibliographic Details
Main Authors: Xiao Zhang, Zhiyang Zhang, Jia Guo, Jing Ma, Songqiang Xie, Yuan Zhao, Chaojie Wang
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
OGT
Peptide recognition
Conformation changes
Umbrella sampling
Hydrogen bond
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037021001203

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