Autonomic Nervous System Is Related to Inhibitory and Control Function Through Functional Inter-Region Connectivities of OFC in Major Depression

• Main Authors: Zhou H, Hua L, Jiang H, Dai Z, Han Y, Lin P, Wang H, Lu Q, Yao Z
• Format: Article
• Language: English
• Published: Dove Medical Press 2020-01-01
• Series: Neuropsychiatric Disease and Treatment
• Subjects: major depression; magnetoencephalography; heart rate variability; functional connectivity; the orbit-frontal cortex
• Online Access: https://www.dovepress.com/autonomic-nervous-system-is-related-to-inhibitory-and-control-function-peer-reviewed-article-NDT

Hongliang Zhou, 1 Lingling Hua, 1 Haiteng Jiang, 2 Zongpeng Dai, 2 Yinglin Han, 1 Pinhua Lin, 1 Haofei Wang, 1 Qing Lu, 2, 3 Zhijian Yao 1, 4 1Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, People’s Republic of China; 2School of Biological Sciences & Medical Engineering, Southeast University, Nanjing 210096, People’s Republic of China; 3Child Development and Learning Science, Key Laboratory of Ministry of Education, Nanjing 210096, People’s Republic of China; 4Nanjing Brain Hospital, Medical School of Nanjing University, Nanjing 210093, People’s Republic of ChinaCorrespondence: Zhijian YaoDepartment of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, People’s Republic of ChinaTel [phone]Fax [phone]Email [e-mail] LuSchool of Biological Sciences & Medical Engineering, Southeast University, Nanjing 210096, People’s Republic of ChinaTel/Fax [phone]Email [e-mail]: To investigate the mechanism of interactions between autonomic nervous system (ANS) and cognitive function in Major depression (MD) with Magnetoencephalography (MEG) measurements.Methods: Participants with MD (n = 20), and Health controls (HCs, n = 18) were completed MEG measurements during the performance of a go/no-go task. Heart rate variability (HRV) indices (SDANN, and RMSSD) were derived from the raw MEG data. The correlation analysis of the HRV and functional connectivities in different brain regions was conducted by Pearson’s r in two groups.Results: The go/no-go task performances of HCs were better than MD patients; HRV indices were lower in the MD group. Under the no-go task, a brain MEG functional connectivity analysis based on the seed regions of the orbitofrontal cortex (OFC) displayed increased functional inter-region connectivity networks of OFC in MD group. HRV indices were correlated with different functional inter-region connectivity networks of OFC in two groups, respectively.Conclusion: ANS is related to inhibitory and control function through functional inter-region connectivity networks of OFC in MD. These findings have important implications for the understanding pathophysiology of MD, and MEG may provide an image-guided tool for interventions.Keywords: major depression, magnetoencephalography, heart rate variability, functional connectivity, the orbitofrontal cortex